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deoxyribonucleosides

Deoxyribonucleosides are a class of nucleosides composed of a deoxyribose sugar attached to a nitrogenous base. The sugar is 2-deoxyribose, lacking the 2' hydroxyl group found in ribose, which contributes to the greater chemical stability of DNA compared with RNA.

Attachment occurs through a glycosidic bond between the 1' carbon of deoxyribose and the nitrogen atom of

In cells, deoxyribonucleosides serve as precursors to deoxyribonucleotides through phosphorylation by specific kinases. Salvage pathways recycle

In medicine, deoxyribonucleoside analogs are used as antiviral and anticancer agents when modified; examples include zidovudine

the
base:
N9
for
purines
adenine
and
guanine,
and
N1
for
pyrimidines
cytosine
and
thymine.
The
four
canonical
deoxyribonucleosides
are
deoxyadenosine
(dA),
deoxyguanosine
(dG),
deoxycytidine
(dC),
and
deoxythymidine
(dT).
bases
or
nucleosides;
nucleoside
phosphorylases
can
cleave
the
glycosidic
bond
to
yield
the
base
and
deoxyribose-1-phosphate.
These
processes
support
DNA
synthesis
and
repair
by
supplying
the
building
blocks
needed
for
DNA
replication.
(AZT)
and
other
similar
drugs
that
inhibit
DNA
synthesis
by
acting
as
faulty
substrates
for
viral
or
cellular
polymerases.
The
absence
of
the
2'
hydroxyl
group
influences
their
chemical
reactivity
and
interactions
with
polymerases,
distinguishing
them
from
ribonucleosides.