degranulates

Degranulation is a biological process in which granules within cells release their contents. This process is commonly observed in immune cells, particularly in mast cells, basophils, and eosinophils, where it plays a crucial role in the body's defense against pathogens and allergens. Granules contain various substances, including histamine, proteases, and cytokines, which are rapidly released upon stimulation. This release can lead to inflammation, vasodilation, and increased vascular permeability, contributing to the body's response to injury or infection. Degranulation is tightly regulated to ensure that the immune response is both effective and controlled, preventing excessive inflammation and tissue damage. The process involves the fusion of the granule membrane with the plasma membrane, allowing the contents to be expelled into the extracellular space. Degranulation is a key mechanism in the body's innate immune response and is also involved in allergic reactions and certain types of hypersensitivity.