bileacidtargeted

Bile acid targeted refers to therapeutic strategies or delivery systems designed to specifically interact with or deliver agents to bile acids or the metabolic pathways involving bile acids. Bile acids are crucial for fat digestion and absorption in the intestine, and their metabolism plays a significant role in various physiological processes. Disruptions in bile acid homeostasis are implicated in a range of diseases, including liver diseases like cholestasis and non-alcoholic fatty liver disease, as well as metabolic disorders such as diabetes and obesity.

Bile acid targeted approaches aim to leverage the unique properties of bile acids to enhance the efficacy or reduce the side effects of certain treatments. This can involve developing drugs that mimic or antagonize bile acid receptors, such as the Farnesoid X receptor (FXR) or the TGR5 receptor. Alternatively, it can involve conjugating therapeutic molecules to bile acids to facilitate their uptake into the liver, where bile acid synthesis and metabolism primarily occur. This targeted delivery can improve the concentration of the drug at its site of action, potentially reducing systemic exposure and off-target effects. Research in this area is ongoing, exploring new ways to modulate bile acid signaling for therapeutic benefit in a variety of conditions.