acrylCoA

Acryl-CoA is a metabolic intermediate involved in the breakdown of certain amino acids and fatty acids. It is formed from the deamination of propionyl-CoA, an important product of fatty acid beta-oxidation and the metabolism of odd-chain fatty acids. Acryl-CoA can also be derived from the catabolism of amino acids like alanine, serine, and cysteine.

The key reaction involving acryl-CoA is its hydration to form 3-hydroxypropionyl-CoA. This reaction is catalyzed by the enzyme enoyl-CoA hydratase. 3-hydroxypropionyl-CoA is then further metabolized. In some organisms, this pathway leads to the production of acetyl-CoA, which can enter the citric acid cycle for energy production. In other pathways, such as the degradation of propionate, it can be converted to succinyl-CoA. The presence and activity of enzymes involved in acryl-CoA metabolism are crucial for efficient energy utilization and the detoxification of certain metabolic byproducts. Dysregulation of these pathways can have implications for metabolic health.