acentrosomális

Acentrosomális, derived from the term "acentrosomal," refers to a condition in which cells lack a centrosome, a crucial organelle involved in cell division and organization of the cytoskeleton. Centrosomes are typically composed of a pair of centrioles surrounded by pericentriolar material, and they play a vital role in determining the position of the mitotic spindle during cell division. In acentrosomális cells, the absence of centrosomes can lead to defects in cell division, as the spindle assembly checkpoint is not properly activated, resulting in aneuploidy and chromosome mis-segregation. This condition can be observed in various cell types and organisms, and it has been implicated in several diseases, including cancer and neurodegenerative disorders. The mechanisms underlying the formation of acentrosomális cells are not fully understood, but they are thought to involve the dysregulation of centrosome-related proteins and signaling pathways. Research into acentrosomális cells and their role in disease is an active area of investigation in the field of cell biology.