Wiperin

Wiperin is a protein found in eukaryotes, playing a role in cellular processes. It is a component of the spliceosome, the complex machinery responsible for removing introns from pre-messenger RNA (pre-mRNA) during RNA splicing. Specifically, Wiperin is associated with the U4/U6 di-snRNP, a crucial intermediate in the spliceosome assembly pathway. Its function within this complex is thought to be involved in spliceosome remodeling and activation, facilitating the precise catalytic steps of splicing.

The gene encoding Wiperin is conserved across various eukaryotic species, suggesting an essential function. Research has indicated that disruptions in Wiperin function can lead to defects in RNA splicing and potentially impact gene expression. Studies have also explored its involvement in other cellular processes beyond basic RNA splicing, though these roles are less well-defined. The precise molecular mechanisms by which Wiperin contributes to spliceosome dynamics and its potential broader cellular roles continue to be areas of active investigation in molecular biology.