WAVEArp23säätelyn
WAVEArp23säätelyn refers to the regulation of WAVE (Wiskott-Aldrich syndrome protein family verprolin-homologous protein) and Arp2/3 (actin-related protein 2/3) complex activity in cells. This complex pathway is crucial for the formation of branched actin networks, which are essential for various cellular processes such as cell motility, cell division, and membrane trafficking. WAVE proteins act as activators of the Arp2/3 complex, while the Arp2/3 complex itself is the core machinery that nucleates new actin filaments.
The WAVE-Arp2/3 pathway is tightly regulated by a variety of upstream signaling molecules and scaffold proteins.
Disruptions in WAVE-Arp2/3 pathway regulation are implicated in several human diseases, including certain types of cancer,