VPS34tl

VPS34tl is a protein found in humans and other mammals. It is a component of the vacuolar protein sorting 34 complex, also known as the PI3K-III complex. This complex plays a crucial role in autophagy, a cellular process responsible for degrading and recycling damaged organelles and misfolded proteins. VPS34tl specifically is the catalytic subunit of the VPS34 complex, meaning it possesses the enzymatic activity required for its function. The complex is responsible for generating phosphatidylinositol 3-phosphate (PI3P), a lipid that acts as a signaling molecule and a scaffold for the recruitment of other proteins involved in autophagosome formation. Dysregulation of the VPS34 complex and autophagy has been implicated in various diseases, including cancer, neurodegenerative disorders, and infectious diseases. Research into VPS34tl and its role in cellular processes continues to be an active area of investigation.