VKORC1L1

VKORC1L1, also known as Vitamin K epoxide reductase complex subunit 1-like 1, is a gene located on human chromosome 17. This gene encodes a protein that is structurally similar to the catalytic subunit of the vitamin K epoxide reductase complex (VKORC), which is essential for the vitamin K cycle. The vitamin K cycle is critical for the post-translational modification of certain proteins, including clotting factors, through gamma-carboxylation. While VKORC1 is the primary enzyme responsible for this carboxylation, VKORC1L1's precise physiological role is not fully understood.

Research suggests that VKORC1L1 may play a role in regulating vitamin K metabolism, potentially acting as a modulator or alternative pathway for vitamin K epoxide reduction. However, its contribution to hemostasis and other vitamin K-dependent processes appears to be less significant than that of VKORC1. Studies have investigated the potential involvement of VKORC1L1 in various conditions, but a definitive link has not been firmly established. Its exact function continues to be an area of active scientific inquiry.