UBR5

UBR5, also known as ubiquitin protein ligase E3A, is a human gene that encodes an E3 ubiquitin ligase. This enzyme is a crucial component of the ubiquitin-proteasome system, which is responsible for the degradation of proteins within cells. UBR5 plays a role in a variety of cellular processes, including DNA repair, cell cycle regulation, and signal transduction. It targets specific proteins for ubiquitination, marking them for destruction by the proteasome. Dysregulation of UBR5 has been implicated in the development of certain cancers. Research suggests that UBR5 can act as an oncogene or a tumor suppressor, depending on the cellular context and the specific proteins it targets. Its involvement in DNA damage response pathways also makes it a potential target for cancer therapies aimed at enhancing the sensitivity of cancer cells to DNA-damaging agents. The precise mechanisms by which UBR5 exerts its functions and its role in disease are areas of ongoing scientific investigation.