TNFRSF21

TNFRSF21, also known as TR2 or DR6, is a protein that belongs to the tumor necrosis factor receptor superfamily. It is encoded by the TNFRSF21 gene. TNFRSF21 is a type I transmembrane protein that plays a role in cell signaling pathways. It is expressed in various tissues, including the nervous system, immune cells, and certain cancer cells.

The protein functions as a receptor for death ligands, although its specific ligands are still under investigation. Activation of TNFRSF21 can trigger different cellular responses depending on the context. In some cases, it has been implicated in promoting apoptosis, or programmed cell death. In other contexts, it may be involved in cell survival, proliferation, or differentiation.

Research has explored the involvement of TNFRSF21 in several biological processes and diseases. It has been studied in relation to neurodegenerative disorders, autoimmune diseases, and cancer. Alterations in TNFRSF21 expression or function have been observed in certain pathological conditions, suggesting a potential role in disease pathogenesis. Its precise mechanisms of action and therapeutic potential are active areas of ongoing research.