TFVIIaXa

TFVIIaXa refers to the activated form of coagulation factor VII, denoted as VIIa, in complex with coagulation factor Xa. This complex is a key component of the extrinsic pathway of blood coagulation. Factor VIIa, upon binding to tissue factor (TF), initiates the coagulation cascade by activating factor X to factor Xa. Once factor Xa is formed, it can then bind to factor VIIa, forming the TF-VIIa-Xa complex. This ternary complex significantly enhances the catalytic activity of factor Xa, leading to the rapid generation of thrombin, which is essential for clot formation. The TF-VIIa-Xa complex plays a crucial role in hemostasis and is also involved in pathological thrombosis. Understanding this complex is vital in the study of bleeding disorders and thrombotic diseases, and it has been a target for therapeutic interventions.