Sullimmunometabolismo

Sullimmunometabolismo refers to the intricate interplay between the immune system and metabolic processes within an organism. This bidirectional relationship means that immune cells are not only influenced by metabolic status but also actively participate in regulating metabolism. Nutrient availability and cellular energy levels profoundly impact immune cell function, differentiation, and effector responses. For instance, immune cells require significant energy to perform their duties, and their metabolic pathways adapt based on the prevailing physiological conditions.

Conversely, immune responses can significantly alter systemic metabolism. Inflammatory signals, a hallmark of immune activation, can lead to changes in glucose, lipid, and amino acid metabolism in various tissues. This can manifest as insulin resistance, altered lipogenesis, and muscle catabolism. The concept of sullimmunometabolismo is crucial for understanding a wide range of physiological and pathological states, including infection, chronic inflammation, autoimmune diseases, cancer, and metabolic disorders like obesity and type 2 diabetes. Research in this area seeks to elucidate the molecular mechanisms governing these interactions to develop novel therapeutic strategies targeting immune-metabolic dysregulation.