Steap3

Steap3, also known as STEAP3 or STEAP homolog 3, is a protein-coding gene. The protein it encodes is a transmembrane metalloreductase. This means it has a role in reducing metal ions, particularly iron. Steap3 is primarily expressed in developing red blood cells and in the testes. Its function in red blood cell development is thought to be related to iron metabolism, which is crucial for hemoglobin synthesis. In the testes, its role is less understood but may be involved in spermatogenesis. The protein localizes to the plasma membrane and the endosomal system. Mutations in the gene have been linked to certain rare genetic disorders, although research in this area is ongoing. Steap3 is a member of the STEAP family of proteins, which share a conserved domain and are involved in redox reactions. Understanding the precise biological functions of Steap3 is important for comprehending iron homeostasis and its implications in various physiological and pathological processes. Further research continues to elucidate its specific molecular mechanisms and potential therapeutic targets.