SLCO1C1

SLCO1C1, also known as solute carrier organic anion transporter family member 1C1, is a protein encoded by the SLCO1C1 gene. This gene is located on human chromosome 11q24.1. The SLCO1C1 protein is a transmembrane transporter belonging to the OATP (Organic Anion Transporting Polypeptide) family.

This transporter plays a crucial role in the uptake of various organic anions across cell membranes. It is predominantly expressed in the brain, particularly in the choroid plexus, which is responsible for producing cerebrospinal fluid. SLCO1C1 is believed to be involved in the transport of thyroid hormones, such as thyroxine (T4), and potentially other substrates into the central nervous system. This function is critical for normal brain development and function.

Variations in the SLCO1C1 gene have been associated with certain neurological conditions and altered responses to medications. Research continues to explore the full spectrum of substrates transported by SLCO1C1 and its precise physiological roles. Its specific location and function suggest it is a key player in regulating the internal environment of the brain.