SEC25

SEC25, also known as VPS35, is a protein-coding gene. It plays a crucial role in the vacuolar protein sorting pathway, a fundamental process in eukaryotic cells responsible for directing proteins to their correct cellular destinations, primarily the vacuole or lysosome. The protein encoded by SEC25 is a subunit of the retromer complex, a protein assembly that is essential for the retrieval of specific cargo proteins from endosomes back to the trans-Golgi network. This retrograde transport is vital for maintaining the proper function of cellular organelles and for recycling of membrane components. Mutations in SEC25 have been linked to various cellular defects and are associated with certain neurological disorders. Research into SEC25 continues to explore its precise mechanisms of action and its broader implications in cellular trafficking and disease pathogenesis.