RhebGTPdriven

RhebGTPdriven is a protein complex that plays a crucial role in the regulation of cell growth and proliferation. It is composed of three main components: Rheb, a small GTPase, and two regulatory proteins, Rheb-binding protein (RBP) and Rheb-binding protein-associated protein (RBPAP). The complex is activated when Rheb is in its GTP-bound state, which is facilitated by the binding of RBP and RBPAP to Rheb. This activation leads to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1), a key regulator of cell growth and proliferation. The RhebGTPdriven complex is involved in various cellular processes, including cell cycle progression, autophagy, and metabolism. It is also a target for several therapeutic agents, including rapamycin and its derivatives, which inhibit mTORC1 and activate the RhebGTPdriven complex. The RhebGTPdriven complex is a well-studied protein complex with significant implications for cancer biology and therapeutic development.