RNF8RNF168

RNF8RNF168 refers to a complex of two ubiquitin ligases, RNF8 and RNF168, that play crucial roles in DNA damage response pathways. RNF8 is an E3 ubiquitin ligase that initiates the ubiquitination of histone proteins at sites of DNA double-strand breaks (DSBs). This initial ubiquitination event is critical for recruiting downstream DNA repair factors. Following RNF8's action, RNF168 further amplifies the ubiquitination signal, particularly targeting histone H2A and H2B. RNF168's activity is essential for the efficient recruitment of other key DNA repair proteins, including MDC1 and 53BP1, which are central to the non-homologous end joining (NHEJ) repair pathway. The coordinated action of RNF8 and RNF168 creates a robust ubiquitination platform that facilitates DNA repair and also plays a role in maintaining genome stability. Dysregulation of this complex can lead to impaired DNA repair, increased genomic instability, and potentially contribute to cancer development. Research into the RNF8RNF168 complex continues to shed light on the intricate mechanisms governing DNA repair and its implications for cellular health and disease.