RESTCoRESTLSD1HDAC

RESTCoRESTLSD1HDAC refers to a specific protein complex involved in epigenetic regulation. This complex is a variant of the larger REST corepressor system, which plays a crucial role in gene silencing. The designation LSD1HDAC indicates the presence of two key enzymatic components: Lysine-Specific Demethylase 1 (LSD1) and Histone Deacetylase (HDAC).

LSD1 is an enzyme that removes methyl groups from specific lysine residues on histone proteins. This demethylation can alter the chromatin structure, making genes less accessible for transcription and thus leading to gene silencing. HDACs, on the other hand, remove acetyl groups from histones, which also contributes to the condensation of chromatin and gene repression.

The RESTCoRESTLSD1HDAC complex functions by bringing these enzymatic activities together in proximity to target genes. It is recruited to specific DNA sequences by the REST (Repressor Element 1-Silencing Transcription factor) protein. Once bound, the LSD1 and HDAC components work in concert to modify histones, effectively switching off the expression of genes that are typically active in neurons but should be silenced in other cell types. Dysregulation of this complex has been implicated in various neurological disorders and cancers.