Pericentriáris

Pericentriáris is a term used in biology, specifically in cell biology, to describe the region immediately surrounding the centrosome. The centrosome itself is a key organelle involved in cell division, acting as the main microtubule-organizing center in animal cells. The pericentriáris region is a complex and dynamic area that plays a crucial role in the formation and organization of microtubules, which are essential components of the cytoskeleton and the mitotic spindle.

This region is characterized by a distinct protein composition that differs from the rest of the cytoplasm. It is a hub for the recruitment and assembly of various proteins, including pericentriolar material (PCM) components, which are vital for nucleating microtubule growth. The PCM is a proteinaceous cloud that surrounds the centrioles within the centrosome, and the pericentriáris encompasses this material and its associated structures.

The pericentriáris is important for several cellular processes beyond mitosis. It contributes to maintaining cell shape, intracellular transport, and cell motility by influencing the organization of the microtubule network throughout the cell. The precise composition and organization of the pericentriáris can change depending on the cell cycle stage and cellular needs, highlighting its dynamic nature and importance in cellular regulation. Aberrations in pericentriáris function have been linked to various diseases, including cancer, underscoring its significance in maintaining normal cellular and organismal health.