PepT1transportterin

The PepT1 transporter, also known as solute carrier family 15 member 1 (SLC15A1), is a protein that plays a crucial role in the uptake of di- and tripeptides across cell membranes. This transporter is primarily found in the intestinal epithelium, where it is responsible for the absorption of dietary peptides, as well as in other tissues such as the kidney and brain, albeit at lower levels. PepT1 functions as a proton-coupled symporter, meaning it uses the electrochemical gradient of protons to drive the transport of peptides. Its substrate specificity extends to a variety of peptides, including those containing amino acids, and it is also recognized by certain drugs, making it a significant target for oral drug delivery systems. The expression of PepT1 can be influenced by factors like diet and disease states, and its dysregulation has been implicated in various physiological and pathological processes. Understanding the function and regulation of PepT1 is important for both nutrition science and pharmaceutical development.