POU2AF1

POU2AF1, also known as OBF1 or Bob1, is a gene that encodes a protein of the POU-domain family. This protein plays a crucial role in the development and function of B lymphocytes, a type of white blood cell essential for the adaptive immune system. The POU2AF1 protein acts as a transcriptional coactivator, meaning it helps other proteins regulate gene expression. Specifically, it interacts with the POU-domain transcription factor Oct-2 to activate genes involved in B cell activation and antibody production. This interaction is vital for the proper maturation and differentiation of B cells. Mutations or dysregulation of POU2AF1 have been linked to various immune deficiencies and certain types of B cell lymphomas. Research into POU2AF1 continues to shed light on the intricate mechanisms governing B cell immunity and the molecular basis of related diseases.