PEX11perhe

PEX11perhe refers to a family of peroxisomal membrane proteins that play a crucial role in peroxisome biogenesis and dynamics. These proteins are characterized by the presence of a transmembrane domain and are involved in regulating the number, size, and shape of peroxisomes within a cell. The PEX11 family is conserved across a wide range of eukaryotic organisms, from yeast to mammals, highlighting its fundamental importance in cellular function.

The primary function of PEX11 proteins is to promote peroxisome division. They are thought to act as fission factors, inducing membrane curvature and facilitating the pinching off of new peroxisomes from existing ones. This process is essential for maintaining an adequate supply of peroxisomes to meet cellular demands. Different members of the PEX11 family may have distinct roles or operate in specific cellular contexts, contributing to the intricate regulation of peroxisome homeostasis.

Dysregulation of PEX11perhe function has been linked to various human diseases. Defects in peroxisome biogenesis can lead to a class of disorders known as peroxisome biogenesis disorders (PBDs), which are characterized by a wide spectrum of neurological and developmental abnormalities. While PEX11 genes themselves are not typically the primary causative genes for the most severe PBDs, their role in peroxisome dynamics means they are indirectly involved in the overall health of peroxisomal function. Research into PEX11perhe continues to shed light on the complex mechanisms governing peroxisome maintenance and their significance for cellular and organismal health.