PAPD4

PAPD4, also known as poly(A) specific ribonuclease catalytic subunit 1, is a protein encoded by the PAPD4 gene. This gene is found in humans and other mammals. PAPD4 is part of a family of enzymes called poly(A) nucleases, which are involved in the degradation of RNA molecules. Specifically, PAPD4 is known to play a role in the deadenylation of messenger RNA (mRNA), a process that shortens the poly(A) tail of mRNA. This shortening is a critical step in regulating gene expression by influencing mRNA stability and translation.

The protein is characterized by its catalytic activity, which allows it to remove adenine nucleotides from the 3' end of RNA molecules. PAPD4's function is essential for maintaining cellular homeostasis and responding to various cellular signals. Research has indicated that alterations in PAPD4 expression or activity can be linked to certain diseases, although the exact mechanisms are still under investigation. Its involvement in RNA metabolism suggests a broad impact on cellular processes. Further research continues to explore the precise biological roles and potential therapeutic implications of PAPD4.