Oximebased

Oximebased refers to compounds that contain the oxime functional group. An oxime is a chemical compound with the general formula R1R2C=NOH, where R1 and R2 can be organic groups or hydrogen atoms. This functional group is characterized by a carbon-nitrogen double bond and a hydroxyl group attached to the nitrogen atom.

Oximes are formed through the reaction of a carbonyl compound, such as an aldehyde or a ketone, with hydroxylamine. This reaction is known as oximation. The specific structure of the oxime depends on the nature of the original carbonyl compound. For example, reacting an aldehyde with hydroxylamine yields an aldoxime, while reacting a ketone yields a ketoxime.

The oxime functional group exhibits isomerism, specifically E/Z isomerism (or cis/trans isomerism) due to the restricted rotation around the carbon-nitrogen double bond. The presence of two different substituents on the carbon and the nitrogen atom leads to the possibility of two distinct spatial arrangements.

Oximes have various applications in organic chemistry. They are frequently used as intermediates in the synthesis of other organic compounds, such as amines through reduction. They can also serve as protecting groups for carbonyl functionalities. Certain oximes are employed as ligands in coordination chemistry, forming stable complexes with metal ions. Furthermore, some oxime-based compounds have found use in analytical chemistry for the detection and quantification of specific substances, and in the pharmaceutical industry as active ingredients or synthetic precursors.