Nedd4like

NEDD4like is a family of E3 ubiquitin ligases involved in protein ubiquitination. These enzymes play a crucial role in regulating various cellular processes by targeting specific proteins for degradation or altering their function through the attachment of ubiquitin chains. The NEDD4like family is characterized by the presence of a catalytic HECT domain, which is essential for its ligase activity.

Members of the NEDD4like family share a common domain architecture, typically including a C2 domain, a WW domain or multiple WW domains, and the HECT domain. The WW domains are responsible for recognizing and binding to proline-rich motifs on substrate proteins, while the C2 domain is involved in calcium-dependent membrane association. This domain organization allows NEDD4like enzymes to interact with a diverse range of cellular targets.

NEDD4like proteins are implicated in a wide array of biological functions, including endocytosis, viral budding, ion channel regulation, and cell proliferation. Dysregulation of NEDD4like activity has been linked to various diseases, such as cancer, neurological disorders, and infectious diseases. Research into the NEDD4like family continues to uncover their complex roles in cellular homeostasis and disease pathogenesis.