NMNAT1driven
NMNAT1driven refers to biological processes and phenotypes predominantly governed by the activity of NMNAT1, the nuclear nicotinamide mononucleotide adenylyltransferase responsible for generating NAD+ within the nucleus. The term underscores processes that depend on nuclear NAD+ pools for the function of NAD+-dependent enzymes and for maintenance of genomic integrity.
NMNAT1 catalyzes the conversion of nicotinamide mononucleotide and ATP to NAD+ and pyrophosphate. Located mainly in
Biological roles frequently described as NMNAT1driven include maintenance of genome stability, effective DNA damage response, and
Clinically, pathogenic variants in NMNAT1 cause Leber congenital amaurosis type 9 (LCA9), a severe early-onset inherited