NKCC2Aktivität

NKCC2 Aktivität refers to the functional activity of the Na-K-2Cl cotransporter 2, also known as the kidney cotransporter 2 (KCC2). This protein is primarily expressed in the basolateral membrane of the thick ascending limb of the loop of Henle in the kidney. Its main role is to reabsorb sodium, potassium, and chloride ions from the tubular fluid back into the bloodstream. This process is crucial for concentrating urine and maintaining the kidney's ability to regulate electrolyte balance and blood pressure.

The activity of NKCC2 is regulated by various factors, including hormones like vasopressin and atrial natriuretic peptide, as well as intracellular signaling pathways. Dysregulation of NKCC2 activity can lead to conditions such as Bartter syndrome, a group of genetic disorders characterized by salt wasting and electrolyte imbalances. Understanding NKCC2 activity is important for comprehending renal physiology and the pathophysiology of certain kidney diseases. Research continues to explore the precise mechanisms controlling its function and potential therapeutic targets related to NKCC2.