NEK7

NEK7, also known as Never in mitosis gene A-related kinase 7, is a protein-coding gene. It belongs to the NIMA (never in mitosis gene A)-related kinase family, which are serine/threonine kinases. These kinases play crucial roles in cell cycle regulation, particularly during mitosis. NEK7 is involved in various cellular processes, including centrosome duplication, mitotic spindle assembly, and cytokinesis.

Recent research has highlighted NEK7's involvement in inflammatory signaling pathways. It has been identified as a key component of the inflammasome, a multiprotein complex that initiates inflammatory responses. Specifically, NEK7 can activate the NLRP3 inflammasome, which is implicated in the pathogenesis of numerous diseases, including autoimmune disorders, metabolic diseases, and neurodegenerative conditions. The activation of the NLRP3 inflammasome by NEK7 leads to the processing and release of pro-inflammatory cytokines like IL-1β and IL-18.

Dysregulation of NEK7 has been associated with various diseases. Its role in the inflammasome suggests it could be a therapeutic target for inflammatory conditions. Further investigation into NEK7's precise mechanisms of action and its interactions with other cellular components is ongoing to fully understand its contribution to both normal cellular functions and disease processes.