NEDD8adenylate
NEDD8adenylate is a molecular intermediate in the neddylation pathway. Neddylation is a post-translational modification process that involves the covalent attachment of the NEDD8 protein (Neural precursor cell expressed, developmentally down-regulated gene 8) to target proteins. This process is functionally analogous to ubiquitination but involves a distinct ubiquitin-like modifier.
The formation of NEDD8adenylate is a crucial early step catalyzed by the NEDD8-activating enzyme (NAE). NAE
The NEDD8adenylate intermediate is transient and highly reactive, facilitating the subsequent transfer of NEDD8. The neddylation
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