NDR1

NDR1, also known as Nuclear Deadenylase 1, is a protein involved in messenger RNA (mRNA) degradation in eukaryotic cells. It is a key component of the cellular machinery that regulates gene expression by controlling the lifespan of mRNA molecules. Specifically, NDR1 is an exoribonuclease, meaning it removes nucleotides from the 3' end of RNA molecules. It works in conjunction with other proteins to trim the poly(A) tail of mRNA, a process that ultimately leads to the degradation of the mRNA and the cessation of protein synthesis from that transcript. This deadenylation process is a critical step in mRNA turnover, allowing cells to fine-tune the levels of specific proteins in response to changing conditions. Dysregulation of NDR1 activity has been implicated in various cellular processes and diseases, highlighting its importance in maintaining cellular homeostasis. Research into NDR1 continues to shed light on the intricate mechanisms of post-transcriptional gene regulation.