Märkägranulaatiota

Märkägranulaatiota refers to a manufacturing process used in the pharmaceutical and chemical industries. It is a wet granulation technique where a binder solution is added to a powder mixture to form larger agglomerates or granules. This method is employed to improve the flow properties, compressibility, and homogeneity of powders, which are essential for subsequent processing steps like tablet compression or capsule filling.

The process typically involves mixing the active pharmaceutical ingredient (API) and excipients, followed by the addition of a granulating liquid. This liquid can be water, an organic solvent, or a combination, and it contains a binder, which is a substance that helps the particles adhere to each other. The mixture is then agitated to promote the formation of granules. After granulation, the wet mass is dried to remove the solvent and achieve the desired moisture content. Finally, the dried granules may be milled to a specific particle size distribution.

Märkägranulaatiota is particularly useful for powders that are difficult to compress, have poor flow characteristics, or tend to segregate. It can also be used to control the dissolution rate of certain drugs or to mask unpleasant tastes. The choice of binder and solvent depends on the specific properties of the materials being processed and regulatory requirements. Careful control of process parameters, such as binder concentration, liquid addition rate, and drying conditions, is crucial to ensure consistent granule quality and desired product performance.