Märgistikuid

Märgistikuid is a term that appears in a limited number of histology discussions to refer to a structural component of bone marrow. The usage is not widespread, and its precise meaning can vary between sources.

The etymology seems to draw on the Swedish märg (bone marrow) with a suffix that resembles -kuid or -ikuid used in some descriptions, though the exact origin and common usage are not standardized. This contributes to divergent definitions across texts.

In sources that employ it, märgistikuid denotes cord- or network-like stromal tissue within the marrow that contributes to the hematopoietic niche. It is described as containing mesenchymal stromal cells, reticular fibers, adipocytes, endothelial elements, and extracellular matrix, forming a scaffold that interacts with hematopoietic cells.

Distribution and function: Märgistikuid is reported to occur in trabecular regions of the marrow and to form a supportive architecture for hematopoietic stem and progenitor cells. Through cell–cell contacts, signaling cues, and a vascular-adjacent environment, it helps maintain the balance between self-renewal and differentiation in the marrow.

Clinical relevance and status: The term is not standardized in contemporary hematology texts; many discussions favor the terms “bone marrow stroma” or “hematopoietic niche.” The use of märgistikuid may reflect translation variants or historical descriptions. Consequently, the current consensus on its definition and boundaries remains uncertain.

See also: bone marrow, hematopoietic niche, stromal cells, mesenchymal stem cells.