MMCoA
MMCoA refers to the methylmalonyl-CoA thioesterase. This enzyme plays a crucial role in the metabolism of branched-chain amino acids and odd-chain fatty acids. Specifically, it catalyzes the hydrolysis of methylmalonyl-CoA to propionate and CoA. This reaction is a key step in the breakdown of valine, isoleucine, threonine, and methionine, as well as certain fatty acids.
The importance of MMCoA stems from its involvement in preventing the accumulation of toxic intermediates. Inborn
MMCoA also plays a role in the regulation of cellular energy metabolism. By influencing the availability of