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MHCIIMoleküle

MHCIIMoleküle, also known as Major Histocompatibility Complex Class II molecules, are a group of glycoproteins critical for the adaptive immune response. They are primarily expressed on the surface of antigen-presenting cells (APCs), including dendritic cells, macrophages, and B cells. These molecules play a central role in recognizing and presenting exogenously derived peptides to helper T cells (CD4+ T cells), facilitating the activation of adaptive immunity.

MHCIIMoleküle are composed of two transmembrane chains: an alpha (α) chain and a beta (β) chain, both of

The expression and diversity of MHCIIMoleküle are essential for the immune system to recognize a wide range

In addition to their immunological functions, MHCIIMoleküle are involved in the regulation of immune responses and

which
are
encoded
by
genes
within
the
major
histocompatibility
complex
(MHC)
region
of
the
human
genome.
The
peptides
presented
by
MHCIIMoleküle
are
typically
13-25
amino
acids
long
and
originate
from
extracellular
proteins
that
have
been
internalized
and
processed
within
the
cell.
of
pathogens
and
abnormal
cells.
The
genes
encoding
MHCIIMoleküle
are
highly
polymorphic,
allowing
for
a
diverse
set
of
molecules
capable
of
presenting
various
antigens.
This
polymorphism
is
also
a
key
factor
in
tissue
compatibility
and
transplant
rejection.
tolerance.
They
contribute
to
the
development
of
immune
memory
and
are
important
in
vaccine
responses.
Due
to
their
central
role
in
immunity,
abnormalities
or
deficiencies
in
MHCIIMoleküle
can
lead
to
immune
deficiencies,
increased
susceptibility
to
infections,
or
autoimmune
diseases.