MEK3MEK6

MEK3MEK6, also known as MAP3K2 and MAP3K3 respectively, are members of the mitogen-activated protein kinase kinase kinase (MAP3K) family. These are serine/threonine protein kinases that play a crucial role in cellular signaling pathways. They are key components of the MAP kinase cascades, which are involved in regulating a wide range of cellular processes including proliferation, differentiation, survival, and stress responses.

MEK3 and MEK6 specifically function upstream of p38 MAPK (Mitogen-Activated Protein Kinase). Upon activation by upstream signals, such as cellular stress or inflammatory cytokines, MEK3 and MEK6 phosphorylate and activate p38 MAPK. The p38 MAPK pathway, in turn, regulates the expression of genes involved in inflammation, apoptosis, and other cellular functions. Due to their central role in these pathways, MEK3 and MEK6 are implicated in various physiological and pathological conditions, including immune responses, cancer, and neurodegenerative diseases. Research into these kinases continues to explore their precise functions and potential therapeutic applications.