Leukoredukoida

Leukoredukoida refers to the process of reducing the number of white blood cells, also known as leukocytes, in a blood product. This is primarily done to mitigate potential adverse reactions associated with transfusions. White blood cells, while crucial for immune function, can contribute to transfusion-related complications such as non-hemolytic febrile transfusion reactions, alloimmunization, and the transmission of certain viruses.

The leukoreduction process involves filtering blood components, such as red blood cells, platelets, and plasma, to remove a significant portion of the white blood cells. This filtration can occur either pre-storage (removing leukocytes before the blood product is stored) or post-storage (removing leukocytes before transfusion). The goal is to reduce the white blood cell count to a specified level, typically below one million leukocytes per unit of blood product.

Leukoreduction is a standard practice in many blood banking procedures and is particularly important for patients who receive frequent transfusions or are immunocompromised. By minimizing the number of leukocytes, the risk of transfusion-associated immunomodulation, fever, and the potential for viral transmission via white blood cells is significantly reduced, thereby improving patient safety and transfusion outcomes.