LaggingStrand
Lagging strand is the DNA strand that is synthesized discontinuously on the template strand oriented opposite to the direction of fork movement during DNA replication. The two parental strands are separated at replication forks; DNA polymerases can synthesize new DNA only in the 5' to 3' direction, so the lagging strand is produced as a series of short segments called Okazaki fragments.
Each fragment begins with an RNA primer synthesized by primase. DNA polymerase extends from the primer until
During replication, the lagging strand is looped so that its polymerase can move in the same physical
Proper processing and ligation of Okazaki fragments are essential for high-fidelity replication; defects can lead to