LTbetaR1

LTbetaR1, also known as Lymphotoxin beta receptor 1, is a type I transmembrane protein belonging to the tumor necrosis factor receptor superfamily. It plays a crucial role in the immune system, particularly in the development and function of secondary lymphoid organs. LTbetaR1 is expressed on various cell types, including lymphocytes, stromal cells, and endothelial cells. Its primary ligand is Lymphotoxin-beta (LTbeta), a type II transmembrane protein. The interaction between LTbeta and LTbetaR1 triggers signaling pathways that are essential for processes like lymph node formation, Peyer's patch development, and immune cell trafficking. Dysregulation of LTbetaR1 signaling has been implicated in various inflammatory and autoimmune diseases, as well as certain cancers. Research into LTbetaR1 continues to explore its multifaceted roles in immunity and its potential as a therapeutic target.