LTB4reseptorit

Leukotrieeni B4 reseptorit, often abbreviated as LTB4Rs, are a group of G protein-coupled receptors that play a crucial role in the inflammatory response. These receptors are primarily activated by leukotriene B4 (LTB4), a potent lipid mediator derived from arachidonic acid. LTB4 is synthesized by various immune cells, including neutrophils and macrophages, and its release is stimulated by inflammatory signals.

There are two known subtypes of LTB4 receptors: BLT1 and BLT2. BLT1 is characterized by its high affinity for LTB4 and is predominantly expressed on leukocytes, such as T cells, eosinophils, and neutrophils. Activation of BLT1 by LTB4 leads to chemotaxis, the directed migration of these cells to sites of inflammation. This process is vital for recruiting immune cells to combat infection or injury.

BLT2, on the other hand, has a lower affinity for LTB4 and is more widely distributed, found on a broader range of cell types, including endothelial cells and airway smooth muscle cells. While its exact functions are still being elucidated, BLT2 is also involved in inflammatory processes, potentially modulating LTB4's effects and contributing to conditions like asthma and allergic rhinitis. The LTB4 receptor system represents a significant target for therapeutic interventions aimed at modulating inflammatory diseases.