Kinidiini

Kinidiini is a medication primarily used to treat certain heart rhythm disorders, specifically atrial fibrillation and atrial flutter, as well as ventricular tachycardias. It belongs to a class of drugs known as Class Ia antiarrhythmics. Kinidiini works by slowing down the electrical conduction within the heart and prolonging the time it takes for the heart muscle to repolarize. This action helps to restore a normal heart rhythm.

The drug is derived from cinchona bark, the same plant source as quinine. It is administered orally. While effective, kinidiini carries a significant risk of side effects, which can be serious. These include gastrointestinal issues like nausea, vomiting, and diarrhea, as well as neurological effects such as dizziness, headache, and blurred vision. More critically, kinidiini can worsen existing arrhythmias or cause new ones, including Torsades de Pointes, a potentially life-threatening ventricular arrhythmia.

Due to its risk profile and the availability of newer, safer antiarrhythmic drugs, the use of kinidiini has become less common. Its use is typically reserved for specific situations where other treatments have failed or are not suitable. Close monitoring by a healthcare professional is essential when taking kinidiini to manage potential adverse effects and assess its efficacy. Drug interactions are also a concern, and patients should inform their doctor about all other medications they are taking.