Kalretikulin

Kalretikulin is a 펨프ลา predicted transmembrane receptor protein expressed in a variety of cell types, including immune cells and epithelial cells. It is a multifunctional protein involved in cellular processes such as cell-cell interaction, cell adhesion, and cell signaling.

Kalretikulin has been studied primarily for its role in immunology and tolerance. It has been shown to promote tolerance by facilitating the interaction between regulatory T cells and antigen-presenting cells. This interaction leads to the suppression of effector T cell responses and the maintenance of immune homeostasis.

Kalretikulin has also been implicated in the regulation of the epithelial barrier function. It has been shown to play a role in maintaining the integrity of the epithelial layer by regulating the adhesion of epithelial cells to each other. Additionally, kalretikulin has been found to be involved in the pathogenesis of certain diseases, including autoimmune disorders and cancer.

The structure of kalretikulin is characterized by a transmembrane region and an extracellular domain. The extracellular domain has been shown to interact with various ligands, including mucins and cell adhesion molecules. The intracellular domain of kalretikulin is predicted to interact with signaling molecules, including tyrosine kinases and G-protein coupled receptors.

Overall, kalretikulin is a multifunctional protein that plays a critical role in regulating cellular processes, including cell-cell interaction, cell adhesion, and cell signaling. Further research is needed to fully understand the mechanisms by which kalretikulin regulates these processes and its implications in human disease.