K36A

K36A is a gene located on human chromosome 3. It encodes a protein that is part of the keratin family of intermediate filament proteins. Keratins are a group of fibrous structural proteins that are the key components of hair, nails, and the outer layer of skin. Specifically, K36A is a type II keratin, meaning it partners with a type I keratin to form a functional keratin filament.

The expression pattern of K36A is primarily found in the epidermis, the outermost layer of the skin. Its precise role in skin biology is still under investigation, but like other keratins, it is expected to contribute to the structural integrity and protective barrier function of the skin. Mutations in keratin genes are known to cause various skin disorders, including blistering diseases and hair abnormalities. While K36A has been identified, its direct link to specific human diseases is an active area of research. Understanding the function of K36A and its interactions with other keratins could provide insights into the maintenance of skin health and the development of treatments for keratin-related conditions.