ITGA7

The Integrin alpha 7 (ITGA7) gene encodes the alpha 7 subunit of integrins. Integrins are cell surface receptors that play crucial roles in cell-cell and cell-extracellular matrix adhesion. The alpha 7 subunit specifically pairs with the beta 1 (ITGB1) subunit to form the alpha 7 beta 1 integrin heterodimer. This specific integrin is predominantly expressed in skeletal muscle and cardiac muscle tissues.

The alpha 7 beta 1 integrin is known to bind to laminin, a major component of the basal lamina. This interaction is vital for the proper development, maintenance, and function of muscle cells. It contributes to the structural integrity of the muscle fiber and is involved in signaling pathways that regulate cell survival, differentiation, and migration. Dysfunctional ITGA7 has been associated with certain muscular dystrophies, highlighting its importance in muscle health. Mutations in the ITGA7 gene can lead to impaired laminin binding and consequently affect muscle tissue architecture and force generation. Research continues to explore the precise mechanisms by which ITGA7 influences muscle physiology and its implications in various muscle-related diseases.