IL22BP

IL22BP, also known as IL22-binding protein or Soluble IL-22 Receptor 1, is a protein that plays a role in the immune system. It is a secreted form of the IL-22 receptor alpha 1 chain (IL-22RA1). IL22BP functions as a decoy receptor, meaning it can bind to the cytokine Interleukin-22 (IL-22) and prevent it from interacting with its natural cell surface receptors.

IL-22 is a cytokine involved in various immune responses, particularly in the defense against pathogens at mucosal surfaces and in tissue repair. It is produced by immune cells like T cells and innate lymphoid cells. IL-22 exerts its effects by binding to a heterodimeric receptor complex composed of IL-22RA1 and IL-10R2 subunits, which are expressed on epithelial cells and some other cell types.

By sequestering IL-22, IL22BP can modulate the signaling pathways activated by this cytokine. This modulation can lead to a dampening of IL-22-driven inflammatory responses. IL22BP has been observed to be elevated in certain inflammatory conditions, suggesting its involvement in regulating the inflammatory milieu. Its precise physiological and pathological roles are still an active area of research, with potential implications for understanding and treating autoimmune diseases and inflammatory disorders. The exact mechanisms by which IL22BP is regulated and its full spectrum of target interactions are subjects of ongoing scientific investigation.