IGHG2

IGHG2 refers to the gene encoding the human immunoglobulin G heavy chain 2. Immunoglobulin G (IgG) is a type of antibody found in blood and other body fluids that helps the body fight infection. IgG antibodies are divided into four subclasses: IgG1, IgG2, IgG3, and IgG4. The IGHG2 gene is one of several genes located in the immunoglobulin heavy chain locus on chromosome 14. This locus contains a cluster of genes that are essential for the production of all types of immunoglobulin heavy chains.

The IGHG2 gene plays a role in the immune response by contributing to the production of IgG2 antibodies. IgG2 is particularly important for the defense against polysaccharide antigens, which are found in the capsules of many bacteria. Variations or mutations in the IGHG2 gene can potentially affect the levels or function of IgG2 antibodies, which may have implications for an individual's susceptibility to certain infections. Research into IGHG2 and its role in immune function is ongoing, contributing to our understanding of humoral immunity and related disorders.