HOXC13s

HOXC13 is a gene that encodes a protein belonging to the homeobox family. Homeobox genes are a large group of genes that are involved in the development of body structures in animals. Specifically, HOXC13 is part of the HOXC cluster, which is one of four HOX gene clusters found in the human genome. These genes play a crucial role in establishing the anterior-posterior body axis and in specifying the identity of different regions of the developing embryo.

The HOXC13 protein is a transcription factor, meaning it binds to DNA and regulates the expression of other genes. Its precise functions are still being investigated, but it is known to be important for the development of the limbs, particularly the hindlimbs. Studies in model organisms have shown that mutations or deletions in HOXC13 can lead to severe limb abnormalities. Beyond limb development, HOXC13 may also have roles in other developmental processes, though these are less well-characterized. The study of HOXC13 contributes to our understanding of the complex genetic mechanisms that underlie embryonic development.