HNA4

HNA4, also known as HN4 or HNA-4, is a gene that encodes a protein belonging to the HNA family. The HNA proteins are a group of transmembrane receptors that play a role in cell adhesion and signaling. Specifically, HNA4 is associated with the red blood cell surface and is involved in the immune response. It is a major determinant of the human platelet antigen system, which is important in blood transfusion and transplant compatibility. Variations in the HNA4 gene can lead to the development of antibodies against these antigens, which can cause transfusion reactions or alloimmune thrombocytopenia. Research into HNA4 continues to explore its precise functions in hematopoiesis and immunology, as well as its implications for clinical diagnostics and therapeutics. The understanding of HNA4 is crucial for managing patients with certain blood disorders and for ensuring safe blood product administration.