GlcNAcylation
GlcNAcylation is a post-translational modification process in which a glucosamine (GlcN) residue is added to a protein or peptide. This modification is catalyzed by enzymes known as GlcNAc transferases, which transfer the GlcN residue from a donor molecule, such as UDP-GlcNAc, to the acceptor protein or peptide. GlcNAcylation is a common modification found in various biological systems, including eukaryotic cells and some prokaryotes.
The GlcN residue is attached to the acceptor protein or peptide via an N-glycosidic bond, typically to
GlcNAcylation is a reversible process, and the GlcN residue can be removed by enzymes known as GlcNAcases.
The study of GlcNAcylation has gained significant attention in recent years, as it has been implicated in