Gefäßpermeabilität

Gefäßpermeabilität refers to the ability of blood vessel walls, particularly capillaries, to allow the passage of substances. This permeability is crucial for the exchange of nutrients, oxygen, waste products, and immune cells between the blood and the surrounding tissues. The structure of the blood vessel wall, including the presence of endothelial cells and their junctions, plays a significant role in determining its permeability. Factors like inflammation, increased blood pressure, and certain medical conditions can alter Gefäßpermeabilität, leading to the leakage of fluid and plasma proteins into the interstitial space, a phenomenon known as edema. Conversely, a decrease in Gefäßpermeabilität might impede the delivery of essential substances. Understanding Gefäßpermeabilität is vital in various physiological and pathological processes, influencing drug delivery, inflammation resolution, and tissue repair. Endothelial cells form a continuous lining within blood vessels. The degree of tightness or looseness between these cells, known as intercellular junctions, dictates how easily molecules can pass through. In capillaries, this process is a selective one, allowing small molecules and water to move freely while restricting larger molecules and cells. This controlled passage is essential for maintaining homeostasis and enabling vital physiological functions.